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MSC 2009 brought together more than 243 attendees from 18 countries and 100 institutions (MSC 2009 Program). This year's conference program will again bring you a diverse, global perspective on regenerative medicine and adult stem cell therapy.
MSC 2011 • Program
Quick Links to daily schedule:
Monday • Tuesday • Wednesday
Program and Speakers:
Monday, August 22, 2011
12:00 p.m. Welcome to MSC 2011 by Stanton Gerson (Case Western Reserve University)
12:15 p.m. Keynote speaker: Gregory Bonfiglio (Proteus Venture Partners) "Commercialization of Regenerative Medicine: Translating Great Science into Successful Business"
1:00 p.m. Session I: From Research to the Patient
Chair: Elmar Burchardt (Pfizer Regenerative Medicine)
Jan Nolta (University of California Davis) "Mesenchymal Stem Cells for the Sustained in vivo Delivery of Bioactive Factors: Toward the Clinic"
Kim Warren (Lonza) "Cell Characterization: Beyond the Potency Assay"
Elmar Burchardt (Pfizer Regenerative Medicine) "Multistem in Patients with Ulcerative Colitis – A Pfizer Phase II Study"
Randy Yerden (BioSpherix) "Risk Reduction at Point-of-Care in Cell Therapy"
Sanjin Zvonic (Progenitor Cell Therapy) "Beyond Scale-up: Managing Bedside Integrity of Cell Therapy Products in a Commercial Setting"
3:00 p.m. Break with refreshments
3:15 p.m. Session II: Skeletal Tissue and Wound Healing Application of Stem Cells
Chair: George Muschler (Cleveland Clinic)
George Muschler (Cleveland Clinic) - Session introduction
Steven Boyce (University of Cincinnati) "Wound Healing and Regeneration with Engineered Skin Substitutes"
Johnny Huard (University of Pittsburgh) "Tissue engineering based on muscle-derived stem cells: Potential applications for tissue regeneration"
Riitta Suuronen (University of Tampere) "Successful clinical bone reconstructions with adipose tissue derived stem cells"
5:00 p.m. Short Talk Presentations from Submitted Abstracts (Chaired by Arnold Caplan)
Grace Sock Leng Teo (Harvard-MIT) "Mesenchymal Stem/Stromal Cells transmigrate between and directly through TNF-± activated endothelium via a blebbing-associated mechanism "
Ana Reginato (Universidade de São Paulo, Brazil) "Successful Intrauterine transplantation of human immature dental pulp Stem Cells into canine model "
Paula Dolley (Corning Incorporated) "Synthetic surface for long-term culture of Human Mesenchymal Stem Cells in serum-free, xeno-free conditions "
Biju Parekkadan (Harvard) "Bioengineered Human Stem Cell Niches"
Jonathan Kenyon (Case Western Reserve University) "Age Related increase in Microsatellite Instability in Human Mesenchymal and Hematopoietic Stem Cells: Is Loss of MLH1 Responsible for Aging? "
Susanna Narkilahti (University of Tampere, Finland)"Functional oligodendrocyte precursor cells and oligodendrocytes from Human Pluripotent Stem Cells "
Paul Lin (Case Western Reserve University)"Long term engraftment of Mesenchymal Stem Cells in irradiated tissues when delivered by aortic arch injection "
Kenichi Tamama (University of Pittsburgh School of Medicine) "EGFR signaling drives multipotential stromal cells to produce multiple growth factors and cytokines via early growth response gene-1"
Jans Ralph (Cardio3 BioSciences) "Development of a potency assay for c3bs-cqr-1, an autologous cardio-regenerative cell therapy product "
Yao Wei (University of California at Davis Medical Center) "Directing mesenchymal stem cells to bone to increase bone formation or Reversing osteoporosis by directing mesenchymal stell cells to the bone surface"
6:00 p.m. Poster Session with Heavy Hors D'oeuvres and Bar Service
7:30 a.m. Breakfast
8:00 a.m. Session III: Oncological Implications of Adult Stem Cells
Chair: Jeremy Rich (Cleveland Clinic)
Jeremy Rich (Cleveland Clinic) "The Complexity of Tumor Cell Hierarchies"
Frank Marini (Wake Forest University) "Do MSC really home to tumors where they favor tumor growth. If so, can we use them safely?"
Andrew Pecora (NeoStem) "Cellular therapy for cardiovascular disease and oncological implications"
Platform Speaker: Erika Spaeth (University of Texas MD Anderson Cancer Center)"CD44 mediates Mesenchymal Stem Cell migration and incorporation into the tumor microenvironment as tumor associated fibroblasts"
9:45 a.m. Break with refreshments
10:00 a.m. Session IV: Angiogenesis Using Adult Stem Cells
Chair: Marc Penn (Summa Cardiovascular Institute)
Marc Penn (Summa Cardiovascular Institute) "Role of SDF-1 in preventing and treating ischemic heart failure"
Keith March (Indiana University) "Adipose Stem Cells in Angiogenesis, Vasculogenesis and Multi-Organ Tissue Rescue"
Platform Speaker 1: Juliana Woda (Athersys) "Development of an Angiogenic Potency Assay for Clinical Grade Stem Cell Production "
Platform Speaker 2: Pawan Gupta (Manipal Institute of Regenerative Medicine & Stempeutics Research)"A randomized, double blind placebo controlled, single dose study on using bone marrow derived allogeneic mesenchymal stem cells in patients with Critical Limb Ischemia"
Platform Speaker 3: Samirah Gomes (University of Miami)"Nitric oxide suppresses the angiogeneic potential of Mesenchymal Stem Cells "
11:45 a.m. Lunch Discussion “FDA Advisory Board in Cell and Gene Therapy"
Chair: Robert Deans (Athersys)
Stanton Gerson (CWRU)
Mattew Allen (Ohio State University)
Vincent Pompili (Ohio State University)
2:00 p.m. Session V: Neurological Applications of Adult Stem Cells
Chair: Mark Noble (University of Rochester)
Mark Noble (University of Rochester) "New insights into repair of CNS damage: Contributions of precursor cell diversity, astrocyte diversity and physiology to optimizing repair outcomes"
Jerry Silver (Case Western Reserve University) "Studies on the Critical role of Stem Cells after Spinal Cord Injury"
Robert Miller (Case Western Reserve University) "Defining the Cellular and Molecular Basis of MSC-induced Functional Recovery in Animal Models of Multiple Sclerosis"
Platform Speaker: Irina Aizman (SanBio, Inc.) "Quantitative Analysis of Mesenchymal Stromal Cell-Induced Neuropoiesis In Vitro "
3:45 p.m. Break with refreshments
4:15 p.m. Session VI: Cell Based Therapy for Organ Diseases and Regeneration
Chair: Robert Deans (Athersys)
Robert Deans (Athersys) "Cell-based Therapy for Organ Diseases and Regeneration"
Elke Eggenhofer (University Medical Center Regensburg, Germany) "MiSOT - Mesenchymal Stem Cells in Solid Organ Transplantation"
Christof Westenfelder (University of Utah) "Treatment of Acute Kidney Injury in Cardiac Surgery Patients with allogeneic MSCs"
Daniel Weiss (University of Vermont) "Cell Therapy Approaches for Lung Diseases"
Platform Speaker: Tracey Bonfield (CWRU)"Mesenchymal Stem Cells: Milieu Define Efficacy in Models of Asthma and Cystic Fibrosis "
6:15 p.m. Poster Session with Cocktails
7:00 p.m. Banquet Dinner and Keynote Lecture: Gil Van Bokkelen (Athersys) "Transformational opportunities in clinical regenerative medicine – how stem cells could change healthcare as we know it"
7:30 a.m. Breakfast
8:00 a.m. Session VII: Adult Stem Cells in Animal Models and Veterinary Medicine
Chair: Robert Harman (Vet-Stem)
Robert Harman (Vet-Stem) "One Medicine and the FDA…..A Story of Mice and Men (and dogs, cats and horses)"
Michael Conzemius (University of Minnesota) "Naturally-Occurring Comparative Models for Regenerative Medicine in the Dog"
Mark Martinelli (California Equine Orthopedics) "Regenerative Medicine in Equine Orthopedics"
Platform Speaker: Irina Kerkis (Butantan Institute, Brazil)"Potential of equine multipotent adipose tissue derived Mesenchymal Stem Cells for the treatment of endometrosis"
9:45 a.m. Break with refreshments
10:00 a.m. Session VIII: Delivery Sytems, Vehicles and Bioimaging of Adult Stem Cells
Chair: Joe Wagner (OncoCyte)
Joe Wagner (OncoCyte) "Optimizing Mesenchymal Stem Cell-Based Therapeutics"
Boro Dropulic (Lentigen) "Lentiviral Vector Mediated Gene Delivery Into Primary Cells for Therapy"
Zhenghong Lee (University Hospitals Case Medical Center) "Imaging MSC Differentiatiation"
Horst von Recum (Case Western Reserve University) "Mechanical Conditioning and Non-Enzymatic Detachment of Implant-Ready Cell Sheets"
Platform Speaker: Catalin Toma (University of Pittsburgh)"Targeted delivery of mesenchymal stem cells for vascular repair following angioplasty using acoustic radiation force "
12:15 p.m. Lunch Discussion with Scott Bruder (BD) "From Initial Cell Isolation Through Delivery of Validated Stem Cell Products: Weaving Together the Discrete Elements Necessary for Successful Product Development"
1:30 p.m. Session IX: Clinical Trials I
Chair: Katarina LeBlanc (Karolinska University)
Joshua Hare (University of Miami) "Cell-based Therapy for Cardiac Repair: From Concept to Clinic"
Peter Cibur (Pavol Jozef Safarik University in Kosice) "Treatement of Long Bone Nonuntions with Combined Graft Material of Allogenic Bone and Autologous MSCs"
Jakub Tolar (University of Minnesota) "Hematogenous Cells in Skin Regeneration"
3:15 p.m. Break with refreshments
3:30 p.m. Session X: Clinical Trials I
Chair: Silviu Itescu (Mesoblast)
Anthony Ting (Athersys) "Development of Adherent Stem Cell Therapies for Cardiovascular Disease"
Lode Debrabandere (Osiris Therapeutics) "Treatment of inflammatory diseases with cell-based therapy : Prochymal™ for severe refractory acute Graft-versus-Host Disease"
Atta Behfar (Cardio3 Biosciences) "C-Cure Multicenter Trial: Lineage Specified Bone Marrow Derived Cardiopoietic Mesenchymal Stem Cells for Treatment of Ischemic Cardiomyopathy"
5:00 p.m. Session XI: Clinical Trials Review by FDA Panel
Chair: Stanton Gerson (University Hospitals)
Panel members: Katarina LeBlanc (Karolinska University) and Silviu Itescu (Mesoblast)
5:30 p.m. Closing Remarks : Arnold Caplan (Case Western Reserve University)
